Vitamin b12 and health coronary disease
coronary disease is one of prevalent surmise for death in advanced countries, for example the us, and is on the rise in developing countries. Risk factors for coronary disease include elevated low-density lipoprotein (ldl) grades, high blood pressure, low high-density lipoprotein (hdl) grades, obesity, and diabetes [45]. elevated homocysteine grades are besides identified as an impartial risk factor for coronary disease [46-48]. Homocysteine is really a sulfur-containing protein produced from methionine which are specific to blood. Elevated homocysteine grades are belief to promote thrombogenesis, impair endothelial vasomotor function, promote lipid peroxidation, and induce vascular plane muscle proliferation [46,47,49]. Evidence from retrospective, cross-sectional, and prospective studies links elevated homocysteine grades with coronary heart disease and stroke [46,49-58]. Vitamin b12, folate, and Vitamin b6 are going to complete homocysteine metabolism. In the employment of insufficient Vitamin b12, homocysteine grades can rise because of inadequate function of methionine synthase [6]. Succeeds from several randomized controlled trials indicate that compositions of Vitamin b12 and folic acid supplements with or without Vitamin b6 decrease homocysteine grades in those with vascular disease or diabetes plus young adult women [59-67]. In an further one scrutinize, older men and women who took a multiVitamin/multimineral supplement for 8 weeks experienced a significant loss of homocysteine grades [68]. evidence supports a task for folic acid and Vitamin b12 supplements in lowering homocysteine grades, but effects from several enormous prospective studies have not shown why these supplements decrease the opportunity of coronary disease [48,62-67]. In the women%u2019s antioxidant and folic acid cardiovascular scrutinize, women at high risk of coronary disease who took daily supplements containing 1 mg Vitamin b12, 2.5 mg folic acid, and 50 mg Vitamin b6 for 7.three years did not possess a sell outd risk of major cardiovascular events, despite lowered homocysteine grades [65]. one's heart outcomes arresting assessment (hope) 2 trial, including 5,522 sick persons over the age of 54 years with vascular disease or diabetes, form that daily treatment with 2.5 mg folic acid, 50 mg Vitamin b6, and 1 mg Vitamin b12 for an median of a scant years sell outd homocysteine grades and the opportunity of stroke but did not sell out the opportunity of major cardiovascular events [63]. In the western norway b Vitamin intervention trial, including 3,096 sick persons undergoing coronary angiography, daily supplements of .4 mg Vitamin b12 and .8 mg folic acid with or without 40 mg Vitamin b6 for one year sell outd homocysteine grades by 30% but did not work on uncut mortality or the opportunity of major cardiovascular events during 38 months of follow-up [66]. The norwegian Vitamin (norvit) trial [62] plus the Vitamin intervention for stroke arresting trial had similar effects [67]. the american heart institution has figured possible evidence is inadequate to compliment a task for b Vitamins in reducing cardiovascular risk [48].
ไม่มีความคิดเห็น:
แสดงความคิดเห็น